Penn Pulmonary Vascular Cell Center

Cell Resources for the study of Pulmonary Arterial Hypertension (PAH)

PERSONNEL

Dr. Horace DeLisser, MD

Dr. Horace DeLisser, MD

 

As an independent investigator for nearly 20 years Dr. DeLisser has had a program of independently funded vascular biology research that has focus on the role of cell adhesion in (i) leukocyte-platelet-endothelial interactions in acute inflammation, especially in the pulmonary bed; (ii) endothelial-endothelial interactions in angiogenesis; and (iii) tumor cell-endothelial interactions during tumor metastasis.  Specific areas of investigation have included the involvement of PECAM-1 in angiogenesis, lung development and tumor metastasis to lung.  In facilitating these Dr. DeLisser’s laboratory has developed techniques for the isolation of mouse lung endothelial cells, expertise that has been applied to the isolation of vascular cells from human lungs.  Since 2011 he has served as the Director of the Penn Pulmonary Vascular Cell Center.

 
Dr. Steven Kawut, MD, MS

Dr. Steven Kawut, MD, MS

 

Steven M. Kawut, MD, MS is the Director of the Pulmonary Vascular Disease Program, a Senior Scholar in the Center for Clinical Epidemiology and Biostatistics, and a tenured Associate Professor of Medicine and Epidemiology (Full Professor, effective July 1, 2015) at the Perelman School of Medicine at the University of Pennsylvania. He graduated from Harvard College and received his medical degree from the Yale School of Medicine and a master degree in clinical epidemiology from the Perelman School of Medicine. He completed his internal medicine training at the Hospital of the University of Pennsylvania, where he also completed pulmonary fellowship.

His clinical and research interests focus on pulmonary vascular disease and lung transplantation. He has published more than 180 peer-reviewed papers on topics such as pulmonary arterial hypertension, hepatopulmonary syndrome, and right ventricular function. He is currently funded by the National Institutes of Health to perform clinical trials in pulmonary vascular disease, a multicenter cohort study of the risk factors for portopulmonary hypertension, and to mentor junior investigators interested in the pulmonary circulation. He serves on multiple study sections and is a standing member of the Mentored Career Award study section of the NHLBI. He is on the Editorial Board of the American Journal of Respiratory and Critical Care and is an Associate Editor at the European Respiratory Journal. He was inducted into The American Society for Clinical Investigation in 2013.

 
Dr. Kaori Ihida-Stansbury, PhD

Dr. Kaori Ihida-Stansbury, PhD

 

Dr. Ihida-Stansbury received her Bachelor of Pharmacy degree from School of Pharmaceutical Sciences at the Nagasaki University and her PhD degree in Biomedical Science with a focus on Cell & Developmental Biology from the Graduate School of Medicine at the Kagoshima University in Japan.  After seminal postdoctoral work in the study of caveolae mediated endocytosis pathway in endothelial cells with Dr. George Palade at the Univeristy of California at San Diego and vascular cell biology in pulmonary arterial hypertension with Dr. Peter Jones at the University Colorado Health Sciences Center, she was recruited to a Research Associate and promoted to a Research Assistant Professor at the Department of Pathology & Laboratory Medicine at the University of Pennsylvania. Recent her studies have been focused on extracellular matrix (ECM)-dependent vascular cell differentiation and functional maturation in embryo and pulmonary arterial hypertension (PAH).